Brand Names:
Vibramycin, Vibravenos, Doxirobe

Drug Type: Antibiotic


Doxycycline is a broad-spectrum bacteriostatic agent that works by inhibiting protein synthesis. Other similar drugs from the tetracycline class include Oxytetracycline, Tetracycline, and Chlortetracycline. Tetracyclines have activity against gram-positive and gram-negative bacteria, including some anaerobes. It is also active against Chlamydia, Mycoplasmas, and some protozoa, and several rickettsiae. Specific bacteria within the tetracycline's activity range include Escherichia coli, Klebsiella spp, Pasteurella spp, Salmonella spp, Staphylococcus spp, and Streptococcus spp.

The half-life elimination of doxycycline in chickens is 4.8 hours. The bioavailability in chickens is 41.3% (20 mg/kg dose).

Caution: Prolonged treatment can have catabolic and immunosuppressive effects, reduce normal gut flora, and increases the risk of opportunistic secondary infections. Birds with existing liver or kidney disease should be closely observed when given this medication.

Egg Withdrawal Period: Doxycycline is not approved for use in poultry producing eggs intended for human consumption in any country. However, multiple studies have been performed to evaluate the depletion of doxycycline in the eggs of treated hens. It is associated with a 7-day withdrawal period for chickens intended for meat purposes.

Storage/Stability: Doxycycline hyclate tablets and capsules should be stored in tight, light resistant containers at temperatures less than 30°C, and preferably at room temperature (15-30°C). After reconstituting with water, the monohydrate oral suspension is stable for 14 days when stored at room temperature.
  • 400 mg/L drinking water, made fresh daily x 21 days OR 25 mg/kg PO q12h for 21 to 45 days (Vibramycin)
  • 50-100 mg/kg SC, IM q5-7d x 5-7 doses (Vibravenos)
  • Applied topically directly to bumblefoot lesions daily for 28 days (Doxirobe)
  • Photosensitivity
  • Decreased immunity
  • Disruption of normal gut flora
  • More susceptible to infection with secondary pathogens.
  • Cardiac arrhythmias
  • Vision changes
  • Difficulty breathing
  • Diarrhea
  • Calcium
  • Sodium bicarbonate: Concurrent use with tetracyclines may result in formation of non-absorbable complexes; also, concurrent use within 1 to 3 hours of administering may result in decreased absorption of oral tetracyclines because of increased intragastric pH.