Oxytetracycline is a broad-spectrum tetracycline antibiotic known for its activity against a wide range of infections. It was the second of the tetracyclines to be discovered.
Oxytetracycline is indicated for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Pasteurella multocida (Fowl cholera), Escherichia coli, Mycoplasma, and Chlamydia.
It is mostly available in oral formations. Injectable formulations are available for some compounds but may cause necrosis at the site of injection.
Odore, R., et al. Cytotoxic effects of oxytetracycline residues in the bones of broiler chickens following therapeutic oral administration of a water formulation. Poultry science 94.8 (2015)
Pakpinyo, S., & Sasipreeyajan, J Molecular characterization and determination of antimicrobial resistance of Mycoplasma gallisepticum isolated from chickens.. Veterinary microbiology, 125(1-2), 59-65. (2007)
Glisson, J. R., Hofacre, C. L., & Mathis, G. F. Comparative efficacy of enrofloxacin, oxytetracycline, and sulfadimethoxine for the control of morbidity and mortality caused by Escherichia coli in broiler chickens. Avian diseases, 48(3), 658-662. (2004)
Martel, An, et al Susceptibility of Clostridium perfringens strains from broiler chickens to antibiotics and anticoccidials. Avian pathology 33.1 (2004)
Omija, B., E. S. Mitema, and T. E. Maitho Oxytetracycline residue levels in chicken eggs after oral administration of medicated drinking water to laying chickens. Food Additives & Contaminants 11.6 (1994)
Glisson, John R., et al The effect of oxytetracycline on the severity of airsacculitis in chickens infected with Mycoplasma gallisepticum. Avian diseases (1989)
Black, W. D A study of the pharmacodynamics of oxytetracycline in the chicken. Poultry science 56.5 (1977)