Brand Names:
Terramycin, Bio-cox, Robenz, Neo-oxtc, Oxtc, Liquamycin, Engemycin, Alamycin , Cyclosol LA

Drug Type: Antibiotic


Oxytetracycline is a highly active broad-spectrum antibiotic that works by inhibiting protein synthesis. Other similar drugs include Chlortetracycline, Tetracycline, and Doxycycline. Oxytetracycline has activity against gram-positive and gram-negative bacteria, including some anaerobes. It is also active against Chlamydia, Mycoplasmas, and some protozoa, and several rickettsiae. Specific bacteria within the tetracycline's activity range include Escherichia coli, Klebsiella spp, Pasteurella spp, Salmonella spp, Staphylococcus spp, and Streptococcus spp.

Oxytetracycline can be given in drinking water and feed, or SC or IM. With IM administration there is a risk it can cause muscle irritation or necrosis. After IM administration of oxytetracycline (not long-acting), peak levels may occur in 30 minutes to several hours, depending on the volume and site of injection.

Oxytetracycline is readily absorbed after oral administration in fasting birds. Bioavialabilities are approximately 60-80%. The pres­ence of products or foods containing Al, Ca, Mg, or Fe reduce or alter the absorption of the drug. If given in drinking water, it should simultaneously be given in feed as well.

Storage/Stability: Unless otherwise directed by the manufacturer, oxytetracycline HCl and oxytetracycline products should be stored in tight, light-resistant con­tainers at temperatures of less than 40°C (104°) and preferably at room temperature (15-30°C); avoid freezing. Note that if this drug is used after its expiration date, it becomes nephrotoxic.

Caution: High dosages or chronic administration may delay bone growth and healing in young poultry. Tetracyclines in high levels can exert an antianabolic effect which can cause an increase in BUN and/or hepatotoxicity, particularly in patients with preexisting renal dysfunction. As renal function deteriorates secondary to drug accumulation, this effect may be exacer­bated.
  • 5 mg/kg SC, IM q12-24h
  • 2500 mg/L drinking water and 2500 mg/kg feed
Ophathalmic ointment, suspension
  • If given IM, can cause muscle necrosis at the injection site.
  • Nephrotoxic
  • Photosensitivity
  • Decreased immunity
  • Disruption of normal gut flora
  • More susceptible to infection with secondary pathogens
  • Calcium
  • Sodium bicarbonate: Concurrent use with tetracyclines may result in formation of non-absorbable complexes; also, concurrent use within 1 to 3 hours of administering may result in decreased absorption of oral tetracyclines because of increased intragastric pH.