Pentoxifylline, also known as oxpentifylline, is a methylxanthine derivative used to improve blood flow. It is commonly indicated for use in humans with peripheral vascular disease. Pentoxifylline:
- Increases red cell flexibility, enabling passage through damaged capillaries.
- Decreases reperfusion-associated membrane injury and leukocyte adhesion to ischemic tissue.
- Has been shown to significantly improve tissue survival in frostbitten animals, both alone and in combination with aloe vera cream (in rabbits) and aspirin (rats).
Pentoxifylline has been used in birds without adverse effects.
Pentoxifylline may help poultry suffering from conditions such as frostbite, atherosclerosis, and cardiovascular disease. It might also increase healing and strength in poultry recovering from tendon injuries or slipped tendon.