Toltrazuril (Baycox, Tolcox) is an antiprotozoal drug used to treat coccidial infections. Toltrazuril and its principle metabolite ponazuril are triazinetrione antiprotozoal compounds with activity against several genera of the Apicomplexa including Eimeria, Isospora, Hepatozoon, Toxoplasma, Sarcocystis, Neospora, and possibly more.
Toltrazuril has been used in a wide variety of animals to treat coccidiosis, isosporiasis, toxoplasmosis, hepatozoonosis (in dogs), neosporosis, roundworm infections, and equine protozoal meningoencephalitis (EPM) (in horses). Ponazuril was the first form of this drug approved for use in the United States, where it is available as an oral paste and sold for its use in treating EPM in horses.
Drug Form: Toltrazuril is available outside of the United States as a solution for the drinking water of poultry (Baycox solution 2.5% and 10%, Bayer) and as an oral suspension (Baycox 2.5 and 5% suspension, Bayer).
Drug dose: A 2-day treatment of toltrazuril in the drinking water (7 mg/kg) is sufficient to treat intestinal coccidiosis in poultry.