Curcumin


Curcuma longa

Curcumin

Other Names:

TRP, Turmeric Rhizome Powder, Indian Saffron, Haldi, Kunyit.

Benefits

  • Antioxidant
  • Antihelmintic
  • Anti-inflammatory
  • Antibacterial
  • Antiarthritis
  • Antiprotozoal
  • Antitumor
  • Antifungal
  • Antiviral
  • Anticoccidial
  • Hepatoprotective
  • Kidney-protection
  • Immunity
  • Gastroprotective
Turmeric (Curcuma longa) is a perennial herb that belongs to the Zingiberaceae family. It has a long history of use in Chinese and Ayurvedic medicine for its treatment of inflammatory conditions, in addition to its liver protective effects, aid in digestion, anti-cancer and anti-inflammatory properties. It's main active ingredients are curcumin and essential oils. It is also the source of the spice known as turmeric, which is derived from the dried, ground rhizome. Curcumin has a vibrant yellow color which is achieved through the constituent, diferuloylmethane. It is rapidly metabolized, conjugated in the liver, and excreted in the feces when consumed by birds. Specific applications studied in poultry include:
  • Deworming: A 2015 study showed turmeric was beneficial against Ascaridia galli, a common intestinal nematode (roundworm), by significantly reducing the length and width of adult worms present in invested chickens digestive systems. High concentrations of turmeric (600 mg/kg of body weight) showed healing effects and restored the integrity of intestinal mucosa in their gastrointestinal tract.
  • Protection from Mycotoxins: Studies show that supplementation with turmeric (5 mg/kg diet) provided chickens some degree of protection against the toxic effect of mycotoxins on vital organs, such as the liver and kidneys. When supplemented in the diet of ducklings, it was found to reverse the aflatoxin-induced liver damage.
  • Ascites Support: Studies indicate that the addition of 5.0g/kg of TRP is enough to increase the blood saturation and bicarbonate concentration, and reduce the mortality due to ascites and serum MDA content.

Poultry Specific Studies

TypePlant PartDosageSpecific useResultsRef
Broilers200 mg/kg dietimmunitycan enhance birds’ growth performance, behavioural patterns, and immunity by reducing oxidative stress and up-regulating the growth-related gene expressions of broilers under stressful conditions due to a high stocking density.M Hafez et al., 2022
Chickens300 mg/kg of dietliver protection, mycotoxinscan protect against aflatoxin B1-induced necroptosis and inflammation by TLR4/RIPK pathway in chicken liver.S Li et al., 2022
Chickens400 mg/kg feedkidney protectionattenuates all the oxidative stress parameters modified by AFB1 in the chicken kidney, opening new perspectives in the management of aflatoxicosis.S Damiano et al., 2022
Chickens1% of dietGI healthsignificantly decreased erythrocytes, hematocrit, hemoglobin, ileal coliform and lactic acid bacteria counts, while significantly increased the thymus weightS Sugiharto and T Yudiarti 2022
Chickenspowder1% of dietantibacterial, Pasteurella multocidaact as an immune enhancer in broilers against Pasteurella multocida.M Raheem et al., 2021
Broilers100 mg/kg of dietHeat stresssignificantly improved the levels of monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs)A Salah at el, 2021
Hens100 to 200 mg/Kgantioxidant, reproductiveSupplementation dose-dependently improved egg production by 8.67%, 11.58% and 1.56%, respectively, while the feed conversion ratios decreased by 9.50%, 10.74%, and 2.07%, respectively. Furthermore, the eggshell strength greatly improved by 22.22%, 23.22%, and 26.74%, respectively, and the eggshell thickness improved by 61.49%, 76.40%, and 90.06%, respectively. Antioxidative capability, reproductive hormones and immune parameters, etc. were all significantly increased.M Liu et al., 2020
Broilers100 to 200 mg/kg of dietGI healthexhibited some positive responses on antioxidant capacity, lesion score and oocyst shedding, based on the increased growth performance and intestinal permeability, and reduced the lesion scores of duodenum, jejunum and cecum and oocyst shedding. Furthermore, CUR treated chickens had numerically lower oocyst count of Eimeria maxima.S Yadav et al., 2020
Hens250 mg/kg of dietGI healthAlpha- and beta-diversity of iejunal microbial communities were significantly increased, while Proteobacteria and Bacteroidetes were significantly decreased. NF-B in jejunums, and TNF in jejunums, the expression of jejunal IL-12 and IL-4 genes were all upregulated.H Gong et al., 2020
Hens150 mg/kg of dietantioxidant, heat stressImproved productive performance, antioxidant enzyme activity, and immune function in hens suffering from heat stress.M Liu et al., 2020
Chicks1% of dietantibacterial, SalmonellaInhibited intestinal colonization by Salmonella Typhimurium.G Nascimento 2019
Ducks200 to 800 mg/kg of dietGI healthsignificantly prevented the BW and ADG decrease, while decreased the IL-1, TNF and MDA content, and increased the GSH-Px activity in the jejunal mucosa compared with the OTA ducks. Additionally, CUR increased jejunal mucosa occludin and tight junction protein 1 expression and decreased those of associated protein kinase 1. Notably, CUR inhibited the increased expression of apoptosis-related genes, and downregulated mitochondrial transcription factors A, B1 and B2 caused by OTA without any effects on RNA polymerase mitochondrialD Ruan et al., 2018
Hens53 mg/dayantitumor, ovarian tumorsDemonstrated a significant and dose-dependent reduction in ovarian cancer incidence and tumor growth.K Sahin et al., 2018
Broilersrhizome powder5 g/kg of dietascitesReduced the mortality rate due to ascites in broiler chickens. D Daneshyar et al., 2012
Chickens222 mg/kgaflatoxicosisameliorated the adverse effects of AFB1 on serum chemistry in terms of total protein, albumin and -glutamyl transferase activity.N Gowda et al., 2009

References