| Type | Plant Part | Dosage | Specific use | Results | Ref |
|---|---|---|---|---|---|
| Broilers | Liver protection, heat stress | Resveratrol alleviated heat stress-induced liver oxidative damage by enhancing the Nrf2-Keap1 signaling pathway, promoting the growth performance of broilers. | K Ding et al., 2022 | ||
| Broilers | 500 mg/kg of diet | Heat stress, Spleen protection | Had a beneficial effect on white feather broilers' growth performance and anti-inflammatory capacity, suggesting that it might effectively mitigate the deleterious effects of heat stress. RSV could inhibit heat stress-induced activation of splenic NF-B, MAPK, and HSP70, as well as inhibit the activation of mitochondrial apoptotic pathways, thus reducing the splenic inflammatory response in heat-stressed white-feather broilers. | T Meng et al., 2022 | |
| Hens | 600 mg/kg of diet | egg production | able to maintain intestinal and ovarian function and mitigate the negative impact of tBHP challenge on production performance and egg quality. | X Ding et al., 2022 | |
| Hens | 400 mg/kg of diet | liver protection, fatty liver hemorrhagic syndrome | Demonstrated the unique ability of grape pomace and resveratrol to improve physiological traits and gene expression for the prevention of hemorrhagic fatty liver syndrome in laying hens. | O Attallah et al., 2022 | |
| Ducks | 400 mg/kg of diet | GI health | increased the V/C ratio of jejunum and significantly increased the number of goblet cells in jejunum mucosa. Resveratrol activated the SIRT1 signaling pathway, improved the activity of antioxidant enzymes, increased HSPs and tight junction protein mRNA expression upon exposure to acute heat stresses. It further inhibited the NLRP3 inflammasome pathway decreased the secretion of IL-1. | C Yang et al., 2021 | |
| Broilers | 400 mg/kg of diet | Heat stress | improved broiler’s growth under Heat stress by relieving Heat stress’s adverse effects on intestinal morphology and improving the intestinal mucosa’s antioxidant capacity. The mechanism of action may be related to the activation of the Nrf2 signaling pathway induced by resveratrol. | C Wang et al., 2021 | |
| Ducks | 500 mg/kg of diet | antioxidant, GI health | improved the antioxidant capacity of duck ileum by reducing the production of MDA and increasing the activity of T-SOD and CAT. Lipopolysaccharide increased Keap1 at mRNA and protein level and decreased the protein level of Nrf2. | H Yang et al., 2021 | |
| Chickens | 600 ppm of diet | GI health | Enhanced growth performance, improved intestinal morphology, and microbial balance, as well as increased immunity in broiler chickens challenged with E. coli. | H Mohebodini et al., 2019 | |
| Hens | 200-400 mg/kg of diet | antioxidant | Significantly reduced levels of total serum cholesterol and triglycerides and activities of alanine transaminase and aspartate transaminase. | C Zhang et al., 2019 | |
| Broilers | Immunity | improved the growth index of thymus, spleen and bursa Fabricius, and increased the serum level of complement C3 of broilers under heat stress. Demonstrated that diets supplementation with resveratrol could inhibited inflammatory response via inhibited NF-B, MAPK, and PI3K/AKT signaling pathways under heat stress condition. Thus, resveratrol may be act as a nutritional regulator to alleviate heat stress-induced high-activated innate immunity and inflammatory response in broilers. | S He et al., 2019 | ||
| Broilers | 350-500 mg/kg of diet for 14 consecutive days | Heat stress | improved average daily gain and decreased rectal temperature from d 3 when compared with heat-stressed group without resveratrol. It also lowered the contents of corticosterone, adrenocorticotropic hormone, cholesterol, triglycerides, uric acid, malonaldehyde, and activities of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase, increased the levels of triiodothyronine, the ratio of triiodothyronine to thyroxine, total protein, glutathione, and activities of alkaline phosphatase, total superoxide dismutase, catalase, and glutathione peroxidase, though with few fluctuation. | S He et al., 2019 | |
| Hens | 400 mg/kg | liver protection | The results confirmed that a diet supplemented with resveratrol could protect the liver by regulating the level of cell autophagy. The mRNA expression of Bcl-2 was significantly upregulated and the mRNA level of Caspase-3 was significantly down-regulated in the HELP+Res group compared to the HELP group, which suggested that Res may regulate hepatocyte apoptosis function by modulating the relative mRNA levels of Bcl-2 and Caspase-3. | X Wang et al., 2019 | |
| Hens | 400 mg/kg of diet | liver protection, fatty liver hemorrhagic syndrome | effectively attenuated oxidative stress and inflammation in hens with fatty liver hemorrhagic syndrome and that it could be an effective feed additive to protect hens against the disease. | C Xing et al., 2019 | |
| Chickens | 0.5-4g/kg diet | antioxidant | Had a positive effect on performance, lipid-related traits and antioxidant activity. | Z Feng et al., 2017 | |
| Broilers | 400 mg/kg diet | Heat stress, GI health | effective in partially ameliorating the adverse effects of heat stress on intestinal barrier function in broilers by restoring the impaired villus-crypt structure, modifying the profiles of intestinal microfloras, and altering the mRNA expression of intestinal tight junctions- and adherence junctions-related genes. | C Zhang et al., 2017 | |
| Broilers | 200-600 mg/kg of diet | Heat stress | Improved growth performance and reduced oxidative stress in heat-stressed black-boned chickens by increasing serum growth hormone concentrations and modulating the expression of heat shock genes in organs of the immune system. | L Liu et al., 2014 | |
| Chicks | 200-800 mg/kg of diet | immunity | improved growth, protected immunocytes against antigen-induced apoptosis, and upregulated immune response in chickens that received conventional vaccinations. | Zhang, CaiYun, et al., 2014 | |
| Broilers | 0.5-1% of diet | liver protection | Decreased the severity and degree of the liver lesions in birds ingesting aflatoxins in their feed. | M Sridhar et al., 2014 | |
| Quail | 200-400 mg/kg of diet | antioxidant | Inclusion of resveratrol up to 400 mg/kg into quail diets enhanced antioxidant status of birds and eggs. | K Sahin et al., 2010 |
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