Valnemulin (brand name Econor®) is a pleuromutilin antibiotic which acts by the inhibition of the initiation of protein synthesis at the level of the bacterial ribosome. It is currently marketed for veterinary use in pigs for treatment of swine dysentery, ileitis, colitis and pneumonia. Valnemulin shows high activity against Mycoplasma spp. and spirochaetes such as Brachyspira hyodysenteriae and Brachyspira pilosicoli. Valnemulin has little activity against Enterobacteriaceae, such as Salmonella spp. and Escherichia coli.
Valnemulin has shown to be effective for treatment of Mycoplasma gallisepticum infections in chickens.