Brand Names:
Tylan, Angel Eyes, Bio-cox, Tylovet, Tylosin Tartrate

Drug Type: Antibiotic

Tylosin (Tylan)

Tylosin is a broad-spectrum macrolide antibiotic which has similar mechanism of action as erythromycin. Tylosin has effective activity against gram-positive bacteria (Staphylococcus, Streptococcus, Listeria, Erysipelothrix, Enterococcus, Corynebacterium, and Clostridium), Mycoplasma, Chlamydophila, and Pasteurella.

The soluble powder form of Tylosin can be mixed with sterile water (mixed 1:10) and used as an eye spray to aid in the treatment of birds with conjunctivitis (particularly if caused by Mycoplasma).

The injectable solution can be mixed with DMSO (1 ml tylosin/50 ml DMSO) and used for nebulization.

Egg Withdrawal Period: In the United States, Ireland, Australia, and the United Kingdom, tylosin is approved for use in laying poultry producing eggs intended for human consumption when its given in accordance with each product manufacturer s label directions; where it has a 0-day egg withdrawal period.

Storage/Stability: Unless otherwise instructed by the manufacturer, in­jectable tylosin should be stored in well-closed containers at room temperature. Tylosin, like erythromycin, is unstable in acidic (pH <4) media. It is not recommended to mix the parenteral injection with other drugs.

Note: Can be irritating to muscles when administered IM.
  • Administered IM (15-30 mg/kg every 6-12h), orally (50 mg/kg, once daily), or added to drinking water (50 mg/L)
Available as an injectable (50 mg/ml or 200 mg/ml Tylan 200) or as an oral powder.
  • Meloxicam: The risk or severity of methemoglobinemia can be increased when Tylosin is combined with Meloxicam