Veterinary advice should be sought from your local veterinarian before applying any treatment or vaccine. Not sure who to use? Look up veterinarians who specialize in poultry using our directory listing. Find me a Vet

Infectious Bronchitis

Other Names: Avian Infectious Bronchitis, Chicken Coronavirus

Infectious bronchitis (IB) is an acute, highly contagious respiratory disease of chickens, caused by a coronavirus. There are several different serotypes and strains of the infectious bronchitis virus (IBV), which are found worldwide. The disease is associated with nasal discharge, coughing, rales, gasping and sneezing. Hens often lay less eggs than normal and produce abnormal eggs. Young birds are more severely affected by the virus then adult birds, and may develop severe respiratory distress.

Once infected, the virus initially replicates in the trachea, where it causes damage to the epithelium and predisposes the birds to secondary infections with pathogenic bacteria, especially E. coli and Mycoplasma. Depending on the strain of the virus, it may migrate from the trachea to other areas of the chicken's body, such as the kidneys, reproductive organs, or alimentary tract.

There are several vaccines available for prevention of the infectious bronchitis. However, since there are numerous different strains of the virus the vaccine is not always effective. Each vaccine targets a select number of virus serotypes, specific to each country. In North America, the three most common strains that affects the commercial poultry industry are the Massachusetts, Connecticut, and Arkansas 99 IB viruses.

Clinical signs

Clinical signs include watery or frothy exudate in the eyes, coughing, tracheal rales, nasal discharge, and sneezing. Young chicks who are more severely affected may appear depressed, huddling near a heat source, and develop severe respiratory distress.
When young female chicks are affected, it usually causes lasting damage to their reproductive system, and are prone to developing cystic oviducts once they start laying eggs. Adult hens often develop a sudden drop in egg production lasting for 10 to 14 days. They may also lay thin, wrinkled or roughened eggshells with thin, watery albumen. Loss of pigment in brown-shelled eggs is common.

Since the virus has a short incubation period, all birds within a flock develop clinical signs within 24 to 48 hours. The respiratory signs usually resolve within a week, unless the disease is complicated by co-infections with opportunistic bacteria.

Depending on the strain, the virus may cause damage to the bird’s kidneys and/or reproductive organs. If the infection spreads to the kidneys, it often leads to urolithiasis and renal failure. The virus may also cause damage to the bird’s reproductive organs (oviduct and ovary in hens, testes and epididymis in roosters).


IB virus is acquired through inhalation or direct contact with infected birds or indirectly through exposure to a contaminated environment. Droplets containing the virus are expelled during coughing or sneezing, and shed in the feces or on the eggs, from infected birds. The virus is not transmittable from hen to chick through the egg. Once recovered, chickens may remain carriers and shed the virus for up to 15-20 weeks. IBV is easily destroyed by exposure to sunlight and common disinfectants.


During the first week of infection, a trachea swab from the affected bird can be taken and sent to a veterinary diagnostic lab for confirmation of the IBV. After the first week, cloacal swabs are the preferred location. If the chicken has died, samples can be taken from the trachea, cecal tonsils, lung, kidney, testes or oviduct.


There are several types of vaccines available against IBV, which are widely used by the commercial poultry industry. Laying hens and broiler breeders initially receive the live attenuated vaccine administered to young chicks en masse through sprays or via drinking water. Followed by the inactivated vaccine as a booster in 4-6 weeks.

Clinical Signs

Frothy exudate in the eyes
Difficulty breathing
Nasal discharge
Drop in egg production
Thin, wrinkled or roughened egg shells
Loss of pigment color of eggshells
Watery albumin


  • History
  • Clinical Signs
  • Laboratory testing

Reported Cases

  • Case 1: Infectious bronchitis in a Chicks A nephropathogenic strain of Infectious bronchitis virus (IBV) was the cause of high mortality in 2 to 3-week-old chicks. Approximately 100 out of 240 chicks died within a 1-week period. No respiratory signs were observed. All of the seven chicks necropsied had slightly enlarged, very pale kidneys with uratefflled ureters and diffuse, tan, fine stippling. Histologically, acute nephrosis and subacute interstial nephritis was found. The diagnosis was confirmed by virus isolation and PCR and the nephropathogenic aspect was demonstrated by finding abundant IBV antigen in the renal tubules and only small amount in the bronchial epithelium by immunohistochemistry. Ref

  • Case 2: Infectious Bronchitis in a Organic egg farm Infectious Bronchitis virus (IBV) infection was the cause of a reported reduction in egg production and egg shell quality in layers on a small organic egg farm. Diagnosis was based on positive serology titers in all hens and on one submitted hen that had salpingitis and oophoritis with positive IBV immunohistochemical staining. Ref

  • Case 3: Infectious bronchitis virus causing renal damage in a Laying hens Avian urolithiasis syndrome was diagnosed in 14-to-25-week-old chickens from a multiple-age caged-layer complex housing more than 2.5 million chickens. Losses from this syndrome ranged from 0.5 to 1.0% per week. Seven-to-14-week-old pullets from this facility had multifocal renal tubular necrosis leading to interstitial fibrosis, tophus formation, and tubular dilation. A coronavirus was isolated in embryos inoculated with pooled samples of trachea, kidney, and cecal tonsil of 4-week-old pullets. This virus, identified as 85-209, was related to infectious bronchitis virus strain Florida 88 by hemagglutination-inhibition assay. Day-old specific-pathogen-free chicks were inoculated with fifth-embryo-passage amnioallantoic fluid containing this virus. These chicks developed histologic lesions of tracheitis at 5 to 7 days postinoculation. Half the chicks inoculated by eyedrop developed renal tubular necrosis after 7 days. Urolithiasis in the flock investigated was attributed to renal damage by this strain of infectious bronchitis virus occurring in 4-to-7-week-old pullets and progressing to segmental atrophy, hyperplasia, and ureteral stone formation in 14-to-25-week-old chickens. Ref


Supportive careMost birds will recover with supportive treatment. Isolate the bird from the flock and place in a safe, comfortable, warm location (your own chicken "intensive care unit") with easy access to water and food. Limit stress.
AntibioticsMay be indicated to control secondary bacterial infections.
Baicalin (Scutellaria baicalensis) extract100-200 mg/kg of dietFeng, Haipeng, et al 2022; F Yang et al., 2020; Z Wu et al.,2020; Y Zhou et al., 2019; B Yin et al., 2021; M Bao et al., 2022; Z Hu et al., 2022
Forsythoside A (Forsythia suspensa) extract80 mg/kg of feed showed an antiviral preventive and therapeutic effect against infectious bronchitis in chickens.X Wang et al., 2020



  • Vaccinate: There are several types of live and inactivated vaccines available, however the emergence of multiple strands of the virus have made control difficult.
  • Biosecurity
  • Quarantine new chickens before adding them to the flock.

Scientific References

Good Overviews

Age Range

All ages are susceptible but the disease is more severe in young chicks less than 6 weeks old.

Risk Factors

  • Poor biosecurity
  • Stressed and overcrowded birds