Tiamulin hydrogen fumarate (brand name Denagard®) is a semi-synthetic derivative of the diterpene antibiotic pleuromutilin. It is primarily used to treat respiratory infections caused by Mycoplasma
and avian intestinal spirochetosis
caused by Brachyspira
Tiamulin is absorbed relatively quickly when administered orally, and is metabolized in the liver. Tiamulin is eliminated from the bird's body after a withdrawal period of 72 hours. A zero withdrawal period for eggs has been granted in several European Union states.