Brand Names:
Rimadyl


Drug Type: Antiinflammatory, Analgesic

Carprofen

Carprofen (brand name Rimadyl®) is an oral or injectable analgesic anti-inflammatory medication given 'off-label' to pet poultry for pain relief. It belongs to a class of drugs referred to as non-steroidal anti-inflammatory drugs (NSAIDs). It is most frequently prescribed for treatment of minor or chronic pain and inflammation resulting from conditions such as chronic arthritis. It is also given to birds during post surgical recovery. Peak plasma levels of subcutaneously injected carprofen are reached 1 to 2 hours.

One study found that 1 mg/kg of carprofen raised pressure thresholds (decreased response to pressure) for at least 90 minutes after injected subcutaneously. In another study conducted on rapidly growing broiler chickens with chronic lameness, carprofen increased their speed and walking ability.

Caution: Carprofen can interact negatively with aspirin, cortisone-like drugs, and corticosteroids.
  • 5-10 mg/kg IM, IV SID
Oral tablets or injectable
  • Diarrhea
  • Aspirin: The risk or severity of adverse effects can be increased when Carprofen is combined with Acetylsalicylic acid.
  • Allopurinol: Carprofen may decrease the excretion rate of Allopurinol which could result in a higher serum level.
  • Amikacin: Carprofen may decrease the excretion rate of Amikacin which could result in a higher serum level.
  • Amoxicillin: Carprofen may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
  • Ampicillin: Carprofen may decrease the excretion rate of Ampicillin which could result in a higher serum level.
  • Bismuth subsalicylate: The therapeutic efficacy of Bismuth subsalicylate can be decreased when used in combination with Carprofen.
  • Cefadroxil: Carprofen may decrease the excretion rate of Cefadroxil which could result in a higher serum level.
  • Cefapirin: The risk or severity of nephrotoxicity can be increased when Carprofen is combined with Cefapirin.
  • Cephalexin: Carprofen may decrease the excretion rate of Cephalexin which could result in a higher serum level.
  • Dexamethasone: The risk or severity of gastrointestinal irritation can be increased when Dexamethasone is combined with Carprofen.
  • Dextran: The risk or severity of bleeding and hemorrhage can be increased when Carprofen is combined with Dextran.
  • Diazepam: Carprofen may decrease the excretion rate of Diazepam which could result in a higher serum level.
  • Diclofenac: The risk or severity of adverse effects can be increased when Diclofenac is combined with Carprofen.
  • Dihydrostreptomycin: The risk or severity of nephrotoxicity can be increased when Carprofen is combined with Dihydrostreptomycin.
  • Dimethyl sulfoxide:Carprofen may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level.
  • Doxycycline: Carprofen may decrease the excretion rate of Doxycycline which could result in a higher serum level.
  • Enalapril:The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Carprofen is combined with Enalapril.
  • Enrofloxacin:Carprofen may increase the neuroexcitatory activities of Enrofloxacin.
  • Estradiol:Carprofen may decrease the excretion rate of Estradiol which could result in a higher serum level.
  • Folic acid:Carprofen may decrease the excretion rate of Folic acid which could result in a higher serum level.
  • Furosemide:The therapeutic efficacy of Furosemide can be decreased when used in combination with Carprofen.
  • Magnesium sulfate:The risk or severity of hyperkalemia can be increased when Magnesium sulfate is combined with Carprofen.
  • Meloxicam:The risk or severity of adverse effects can be increased when Meloxicam is combined with Carprofen.
  • Methylprednisolone:The risk or severity of gastrointestinal irritation can be increased when Methylprednisolone is combined with Carprofen.
  • Prednisolone:The risk or severity of gastrointestinal irritation can be increased when Prednisolone is combined with Carprofen.
  • Prednisone:The risk or severity of gastrointestinal irritation can be increased when Carprofen is combined with Prednisone.
  • Salicylic acid:The risk or severity of adverse effects can be increased when Carprofen is combined with Salicylic acid.
  • Selenium:Carprofen may decrease the excretion rate of Selenium which could result in a higher serum level.
  • Sulfadiazine:Carprofen may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
  • Tetracycline:Carprofen may decrease the excretion rate of Tetracycline which could result in a higher serum level.
  • Tiludronic acid:The risk or severity of gastrointestinal bleeding can be increased when Carprofen is combined with Tiludronic acid.

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