Brand Names:
Penbritin, Redicilin, Unasyn


Drug Type: Antibiotic

Ampicillin


Ampicillin is a type of antibiotic similar to penicillin, which is used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. Ampicillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Ampicillin results from the inhibition of cell wall synthesis and is mediated through Ampicillin binding to penicillin binding proteins (PBPs). It is indicated for use mainly against infections caused by Escherichia coli, Shigella, Listeria monocytogenes, Salmonella, enterococci, and staphylococci..

Ampicillin has a short half life (2-3 times daily), orally low resorption, and low toxicity.
1000-2000 mg/L drinking water | 100 mg/kg PO, IM q4-12h
  • Amikacin: The serum concentration of Amikacin can be decreased when it is combined with Ampicillin.
  • Apramycin: The serum concentration of Apramycin can be decreased when it is combined with Ampicillin.
  • Chlortetracycline:The therapeutic efficacy of Ampicillin can be decreased when used in combination with Chlortetracycline.
  • Chloroquine: The serum concentration of Ampicillin can be decreased when it is combined with Chloroquine.
  • Gentamicin:The serum concentration of Gentamicin can be decreased when it is combined with Ampicillin.
  • Doxycycline: The therapeutic efficacy of Ampicillin can be decreased when used in combination with Doxycycline.
  • Neomycin: The serum concentration of Neomycin can be decreased when it is combined with Ampicillin.
  • Spectinomycin:The serum concentration of Spectinomycin can be decreased when it is combined with Ampicillin.