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Reticuloendotheliosis is a neoplastic (tumor causing) disease of chickens, caused by a group of reticuloendotheliosis viruses (REVs) belonging to the Retroviridae family. REVs affect a wide range of avian species, including turkeys, ducks, geese, peafowl and pheasants. Reticuloendotheliosis is characterized by immunosuppression, runting-stunting syndrome, chronic lymphomas, and chronic neoplasm, which resemble a combination of Marek's disease and Avian leukosis.
REVs are transmitted horizontally through fecal-oral route, vertically, and accidentally through contaminated vaccines.