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New England Disease, Epidemic Tremor
|Affected||History||Clinical signs||Diagnostic Findings||Tests used||Ref|
|One-day-old chickens||Numerous one-day-old chicks in a hatchery were affected.||Weakness||Necropsy and histopathology of the brain revealed multifocal lesions affecting the large nuclei in the brainstem and cerebellar Purkinje cells, with neuronal degeneration.||Necropsy; histopathology; ELISA||Conference 10-2013 Case: 02 cerebrum, cerebellum, brainstem - Chicken. AskJPC.org|
|Three flocks of 11 - to 14-week-old commerical leghorn pullets||The flocks were vaccinated against fowl pox and AE with a combined product in the wing-web. Two weeks following vaccination, clinical signs appeared in the birds.||Birds 'down on their legs', unilateral recumbency, sitting on hocks, lethargy, reluctance to move, dehydration, unevenness in size, stunted growth, tremors of the head in a few birds, and mildly to moderately elevated mortality.||Necropsy revealed lesions consistent with AE, including lymphocytic perivascular infiltration and neuronal central chromatolysis in the brain and spinal cord and gliosis in the cerebellar molecular layer.||Necropsy; histopathology; reverse-transcriptase PCR||C Senties-Cue et al., 2016|
|An outbreak in one-day-old chicks from multiple hatches on a game farm||The incident occurred on a game farm producing chicks from its own breeding flock. They had recently introduced new roosters to the farm to breed with the hens. Upon hatching and to 7.5 weeks of age, clinical signs appeared. At one-day-old the chicks were bright and alert, but by 3-days-old they were severely affected and appeared dull.||Head tremors (that was made more noticeable when the chicks were upright), incoordination, falling on their backs and unable to right themselves easily, hock-sitting, curled toes, and would sit or lay with their legs at unusual angles. Chicks tended to move about with splayed legs and wings, often falling over. Some chicks went blind. Some chicks had pale grey opacity of one or both eyes by the time they were 3-weeks old.||The histopathology exam of the brain of revealed mild to moderate acute encephalomyelitis, in the brainstem, but not all of the chicks were affected.||Necropsy; blood test; histopathology; ELISA for AEV antibody; PCR||Welchman, D et al., 2009|
|20 out of 300, 12-day-old chicks||The chicks were suspected to have been vertically infected with the virus, from adult breeders.||Dullness, Ataxia, hock-sitting, and recumbency prior to death.||Necropsy and histopathology revealed lesions consistent with AEV.||Necropsy; histopathology||CAHFS Connection, October 2012|
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