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Aceclofenac Toxicity

Aceclofenac is a type of non-steroidal anti-inflammatory drug (NSAID) that is able to convert into diclofenac, a drug which is thought to be responsible for visceral gout in chickens. This is because chickens are uricotelic and lack the enzyme uricase, resulting in the development of uric acid, which is produced by the liver and excreted through the kidneys. The chicken's blood uric acid levels increase as renal filtration is reduced. Chronic consumption of aceclofenac will induce clinical signs of toxicity in chickens.

Clinical Signs

Lethargy
Depression
Drooping of wings
Dehydration
Loss of appetite
Feather plucking
Shrunken eyes
Shifting leg lameness
Inability to stand
Ruffled feathers

Diagnosis

  • Clinical signs
  • History
  • Physical exam
  • Laboratory testing

Treatment

NameSummary
Supportive careIsolate the bird from the flock and place in a safe, comfortable, warm location (your own chicken "intensive care unit") with easy access to water and food. Limit stress. Call your veterinarian.
Diet modificationRemoval from source of aceclofenac

Prevention

Scientific References