Leuprolide acetate (Lupron) is a type of gonadotropin-releasing hormone (GnRH) agonist. It is used for hormone therapy in poultry with reproductive disorders. It accomplishes this by stopping them from laying eggs by stopping the ovaries from making estrogen and progesterone.
Leuprolide acetate has also been used in overly aggressive roosters with excessive sex drives. It acts by preventing their bodies from making more testosterone. Roosters who have received the injection or implant usually initially undergo an increase in testosterone level for the first week, then start to decline by the end of the second week of treatment.
Drug form: Leuprolide acetate is given as an intramuscular (IM) injection or subcutaneously implanted, under the skin. In humans, leuprolide acetate is used for treating prostate cancer in men, endometriosis or uterine fibroids in woman, and early-onset puberty in children.
Typical Dosage: 500-800 µg/kg IM, administered every 14 days. Usually after 3 doses it begins to take effect.