Human chorionic gonadotropin (HCG, Novarel, Ovidrel, Pregnyl) is a polypeptide hormone produced by the human placenta. It has been used by some avian veterinarians to help stop chronic egg-laying in poultry. HCG has demonstrated to be a safer alternative with significantly fewer side effects when compared to other hormone therapy drugs. However, its effects at stopping ovulation (egg laying) have not been consistently effective.
How HCG Works: The use of this hormone is linked to it's primarily luteinizing hormone (LH) alpha sub-unit activity, which results in an increase in progesterone (and some increase of estrogen and testosterone) in female birds. The theory behind it's effectiveness is that high levels of progesterone supplied to the developing follicles causes atresia and stops the development of future developing follicles.
Dosage/form: HCG is given as an IM injection, between 500 to 1,000 IU/kg given initially, and repeated on day three and again on day seven. The treatment will need to be repeated every couple of months.