Cisapride is a gastroprokinetic agent and third-generation benzamide that is used as a motility-enhancement drug, to help increase motility in the upper gastrointestinal tract. Cisapride is a serotonergic agonist which activates acetylcholine release from the mesenteric plexus, which in turn stimulates GI smooth-muscle.
Caution: Cisapride should not be used when increased GI motility may be harmful (mechanical obstruction, impaction, potential perforation or GI hemorrhage).
Caution: Cisapride should not be used with ketoconazole, itraconazole, IV miconazole, or troleandomycin, erythromycin, fluconazole and clarithromycin. These combinations may result in potentially fatal ventricular arrhythmias.
Caution: If used with cimetidine, it may increase the absorption of cisapride.