Amphotericin B is a macrolide antifungal drug used most commonly for treatment of aspergillosis
. It is also effective against: Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Rhodotorula, Blastomyces dermatitidis, Mucor mucedo
, and Sporothrix schenckii
. Additionally, amphotericin B has in vivo
activity against some protozoa species, including Leishmania spp.
and Naegleria spp.
If administered rapidly or if overdosed, it can result in heart arrhythmias and cardio-respiratory arrest. Since the drug is eliminated by the kidneys, it has a high risk of causing kidney damage (nephrotoxicity) and thus should only be used for a short duration.
: Vials of amphotericin B powder for injection should be stored in the refrigerator (2-8°C), protected from light and moisture. Reconstitution of the powder must be done with sterile water for injection.