Brand Names:
Zyloprim, Alloprin, Adenock, Allohexal, Alloril


Drug Type: Antigout

Allopurinol (Zyloprim, Aloprim, Lopurin)


Allopurinol (Zyloprim, Aloprim, Lopurin) is an xanthine oxidase inhibitor. It is used to treat urolithiasis, urate stone dissolution, reperfusion injuries, and leishmaniasis.

Drug form: Allopurinol is available as 100mg or 300mg tablets, or as an injectable powder, 500 mg (Allopurinol sodium - Aloprim).

Recommended dosage: One 100 mg tablet can be crushed and dissolved into 10 ml of sterile water. Up to 1 ml of the diluted mixture can be added to 30 ml of drinking water. Drinking water should be replaced several times a day. Within 2 to 3 days of administering the drug, uric acid levels in serum and urine should be noticeably reduced. When poultry are severely affected, the initial dose should be 25% less than the recommended dose, and gradually increased over several days.

Caution
Extra attention should be made towards ensuring that any birds' taking this drug are always provided access to multiple sources of fresh, clean water so they don't get dehydrated because the drug is potentially nephrotoxic.
  • Dehydration
  • Amoxicillin: The risk of a hypersensitivity reaction to Amoxicillin is increased when it is combined with Allopurinol.
  • Ampicillin: The risk of a hypersensitivity reaction to Ampicillin is increased when it is combined with Allopurinol.
  • Furosemide: The risk or severity of adverse effects can be increased when Furosemide is combined with Allopurinol.
  • Trichlormethiazide: The risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Trichlormethiazide.